You can’t combat your nature, your DNA is what it is but you can change and transform the expression of this DNA and in most cases completely turn off the expression putting the choice of phenotype into your hands.
This requires diligence and determination because you must now remove your nurtured material and replace it with what you’d desire.
It also takes a level of extreme belief in the power of self.
Subconscious Work A.K.A Shadow Work
“Whatever we plant in our subconscious mind and nourish with repetition and emotion will one day become a reality.” — Earl Nightingale
This is where to begin nurture removal processes, in your subconscious there are files on various aspects of life and core belief systems. Finances, love, self, family, sex etc. your behaviors are primarily determined from this area as it is the area deemed to know and understand the world. Without consciously being aware of it you give the upmost trust to your subconscious to create the reality you desire.
However, your subconscious has been assembled through the various experiences negative and positive in your child hood. Heavily impacted between the ages of infancy too eight years of age. So if you were already born (nature) with the genealogy of depression, anxiety, trauma etc. then witnessed (nurture) depression, trauma etc. Your DNA will be supported and your phenotype (expression) will be that of someone who suffers with depression, anxiety and trauma related belief systems.